Last week I built my vSphere Home Lab "The Green Machines". One of the biggest purchases I made for my lab was the Synology DS411+. I bought this NAS because DSM 3.0 is supposed to be "VMware Ready" and it has NFS, iSCSI, and iSCSI Thin Provisioning abilities. During my testing with iSCSI, I noticed some unusual behavior. If i ever put an I/O load on iSCSI, the connection to the VMware ESXi servers would drop off. It wasn't heavy I/O either, the connection would drop during an install of Office 2010 on my Windows 7 VM. The datastore on ESXi would gray out and go italic, but the NFS datastore was still available. I am running the latest DSM 3.0 Build 1372.
To remedy the situation, I would have to go back in to the Synology GUI, restart the iSCSI service, reboot the NAS, then reboot both of my ESXi servers and it was back. I did a quick google search which lead me to this post on the Synology forums ESX 4 and iSCSI problem. This was the same exact symptoms I saw so I opened up a ticket with Synology and sent them my log file. Luckily, they knew the exact problem and already have an undocumented remedy.